Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM606130
Substrate
n/a
Meas. Tech.
Biochemical Selectivity Kinase Assay
Ki
0.060±n/a nM
Citation
Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent US11684616 Publication Date 6/27/2023
More Info.:
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Human
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
Inhibitor
Name:
BDBM606130
Synonyms:
4-[(1R)-1- aminopropyl]- 2-{6-[(5R)-5- (fluoromethyl)- 6,7-dihydro- 5H-pyrrolo[2,1- c][1,2,4]triazol- 3-yl]pyridin-2- yl}-6-[(2R)-2- methylpyrroli- din-1-yl]-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1-one | US11684616, Example 32
Type:
Small organic molecule
Emp. Form.:
C26H31FN8O
Mol. Mass.:
490.5757
SMILES:
CC[C@@H](N)c1nc(cc2C(=O)N(Cc12)c1cccc(n1)-c1nnc2CC[C@H](CF)n12)N1CCC[C@H]1C |r|