Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608380
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
27.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608380
Synonyms:
(Z)-15-chloro-96-fluoro-13,21,25,61- tetramethyl-4-((1-methyl-1H-pyrazol-4- yl)sulfonyl)-11H,21H,61H-10-oxa-8-thia-4- aza-1(4,1)-indola-2(4,3),6(3,5)-dipyrazola- 9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid | US11691989, Compound 36
Type:
Small organic molecule
Emp. Form.:
C39H38ClFN8O5S2
Mol. Mass.:
817.351
SMILES:
Cc1c-2c(CN(Cc3cc(CSc4cc(OCCCn5c(C(O)=O)c(C)c6c-2c(Cl)ccc56)c2ccc(F)cc2c4)n(C)n3)S(=O)(=O)c2cnn(C)c2)nn1C
Structure:
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