Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608389
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
16.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608389
Synonyms:
(Z)-15-chloro-25-(difluoromethyl)-96-fluoro- 13,21,61-trimethyl-4-(methylsulfonyl)- 11H,21H,61H-10-oxa-8-thia-4-aza-1(4,1)- indola-2(4,3),6(3,5)-dipyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid | US11691989, Compound 45
Type:
Small organic molecule
Emp. Form.:
C36H34ClF3N6O5S2
Mol. Mass.:
787.271
SMILES:
Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CN(Cc5nn(C)c(C(F)F)c5-c5c(Cl)ccc2c15)S(C)(=O)=O)nn4C)cc1cc(F)ccc31
Structure:
Search PDB for entries with ligand similarity: