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Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608394
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
20.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608394
Synonyms:
(Z)-15-chloro-96-fluoro-4-(2-methoxyethyl)- 13,61-dimethyl-26,27-dihydro-11H,24H,61H-10- oxa-8-thia-4-aza-2(3,2)-pyrazolo[5,1- c][1,4]oxazina-1(4,1)-indola-6(3,5)-pyrazola- 9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid | US11691989, Compound 50
Type:
Small organic molecule
Emp. Form.:
C39H40ClFN6O5S
Mol. Mass.:
759.289
SMILES:
COCCN1Cc2cc(CSc3cc(OCCCn4c(C(O)=O)c(C)c5c(-c6c(C1)nn1CCOCc61)c(Cl)ccc45)c1ccc(F)cc1c3)n(C)n2
Structure:
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