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Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608395
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
17.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608395
Synonyms:
(Z)-15-chloro-96-fluoro-13,61-dimethyl-4-(2- (methylsulfonamido)ethyl)-26,27-dihydro- 11H,24H,61H-10-oxa-8-thia-4-aza-2(3,2)- pyrazolo[5,1-c][1,4]oxazina-1(4,1)-indola- 6(3,5)-pyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid | US11691989, Compound 51
Type:
Small organic molecule
Emp. Form.:
C39H42ClFN7O6S2
Mol. Mass.:
823.375
SMILES:
Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CN(CCNS(C)(=O)=O)CC5=C(C6=[N](CCOC6)N5)c5c(Cl)ccc2c15)nn4C)cc1cc(F)ccc31 |t:29,31|
Structure:
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