Reaction Details Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM613026
Substrate
n/a
Meas. Tech.
Apoptosis Inhibition Assay
EC50
500±n/a nM
Citation
 Zhang, Z; Wang, X; Huang, S; Jiang, X; Li, L; Zhang, Z; Han, J Apoptosis inhibitors US Patent  US11725000 Publication Date 8/15/2023 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Human
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM613026
Synonyms:
US11725000, Compound 288
Type:
Small organic molecule
Emp. Form.:
C33H38F2N4O6S
Mol. Mass.:
656.74
SMILES:
COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)F)cc1OC |TLB:32:33:30.31.36:37,THB:32:31:37:33.38.34,34:33:30:36.37.35,34:35:30:32.33.38|
Structure:
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