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Target
Tyrosine-protein kinase JAK1
Ligand
BDBM613535
Substrate
n/a
Meas. Tech.
JAK Enzyme Assay
Ki
0.250±n/a nM
Citation
 Crawford, JJ; Zak, M; Kellar, T; Cheng, Y; Li, W; Romero, FA; Gibbons, P; Zhao, G; Hamilton, G; Goodacre, SC Therapeutic compounds, compositions and methods of use thereof US Patent  US11731943 Publication Date 8/22/2023 
Target
Name:
Tyrosine-protein kinase JAK1
Synonyms:
JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1
Type:
Protein
Mol. Mass.:
133293.73
Organism:
Homo sapiens (Human)
Description:
P23458
Residue:
1154
Sequence:
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM613535
Synonyms:
1-[1-(cyanomethyl)-4-[4-(2- furyl)anilino]cyclohexyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide | US11731943, Example 276
Type:
Small organic molecule
Emp. Form.:
C26H28N6O3
Mol. Mass.:
472.5389
SMILES:
NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCC(CC1)Nc1ccc(cc1)-c1ccco1 |(-1.31,4.19,;-2.79,3.79,;-3.88,4.89,;-3.2,2.31,;-2.23,1.11,;-3.08,-.18,;-4.56,.22,;-4.64,1.76,;-5.93,2.61,;-7.3,1.91,;-7.39,.38,;-8.59,2.76,;-9.36,4.09,;-10.13,2.76,;-2.31,-1.51,;-3.8,-1.91,;-4.2,-3.4,;-4.59,-4.89,;-2.31,-3.05,;-.98,-3.82,;.36,-3.05,;.36,-1.51,;-.98,-.74,;1.69,-3.82,;3.18,-3.43,;4.27,-4.51,;5.76,-4.12,;6.15,-2.63,;5.07,-1.54,;3.58,-1.94,;7.64,-2.23,;8.19,-.79,;9.73,-.87,;10.13,-2.36,;8.84,-3.2,)|
Structure:
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