Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2
Ligand
BDBM623977
Substrate
n/a
Meas. Tech.
FGFR2 Biochemical Caliper Assay
IC50
10500±n/a nM
Citation
 Touré, B; Schoenherr, H; Giordanetto, F; Moustakas, DT; Hudson, BM FGFR inhibitors and methods of use thereof US Patent  US11780845 Publication Date 10/10/2023 
Target
Name:
Fibroblast growth factor receptor 2
Synonyms:
BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2
Type:
Enzyme
Mol. Mass.:
92015.45
Organism:
Human
Description:
P21802
Residue:
821
Sequence:
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM623977
Synonyms:
US11780845, Example 997
Type:
Small organic molecule
Emp. Form.:
C29H32N6O2
Mol. Mass.:
496.6034
SMILES:
CC(=C)C(=O)Nc1ccc(cc1)-c1c(C2=CC[C@@H](CC2)C(=O)N2CC3CC2C3)c2c(N)ncnc2n1C |r,wU:17.21,t:15,(7.14,-5.73,;6.37,-4.39,;7.14,-3.06,;4.83,-4.39,;4.06,-5.73,;4.06,-3.06,;2.52,-3.06,;1.75,-4.39,;.21,-4.39,;-.56,-3.06,;.21,-1.73,;1.75,-1.73,;-2.1,-3.06,;-3.01,-1.81,;-2.53,-.35,;-1.02,-.03,;-.55,1.43,;-1.58,2.58,;-3.09,2.26,;-3.56,.79,;-1.1,4.04,;-2.13,5.19,;.4,4.36,;1.03,5.77,;2.56,5.61,;2.88,4.1,;1.55,3.33,;1.55,4.87,;-4.47,-2.29,;-5.8,-1.52,;-5.8,.02,;-7.14,-2.29,;-7.14,-3.83,;-5.8,-4.6,;-4.47,-3.83,;-3.01,-4.31,;-2.53,-5.77,)|
Structure:
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