Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM640357
Substrate
n/a
Meas. Tech.
TR-FRET BRD4 Binding Assay
Ki
<100.0±n/a nM
Citation
 Thatcher, GR; Xiong, R; Zhao, J; Li, Y Pyridinone-based epigenetic modifiers and uses thereof US Patent  US11840533 Publication Date 12/12/2023 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM640357
Synonyms:
N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- pyrrolo[2,3-c]pyridin-3-yl)- 1H-indazol-4- yl)methanesulfonamide | US11840533, Compound 30
Type:
Small organic molecule
Emp. Form.:
C23H20FN5O3S
Mol. Mass.:
465.5
SMILES:
Cn1cc(-c2cc(NS(C)(=O)=O)c3cnn(Cc4ccc(F)cc4)c3c2)c2ccnc(O)c12
Structure:
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