Reaction Details
Report a problem with these data
![](/images/Email.png)
Target
Apoptosis regulator Bcl-2
Ligand
BDBM356741
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki
<0.010±n/a nM
Citation
![](/images/small/blackdot.gif)
More Info.:
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Inhibitor
Name:
BDBM356741
Synonyms:
US10213433, Compound 123 | US11369599, Compound 123 | US20240043404, Example 123 | trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(3-nitro-4-{[4-(tetrahydro-2H-pyran-4-ylamino)cyclohexyl]amino}phenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Type:
Small organic molecule
Emp. Form.:
C50H59ClN8O7S
Mol. Mass.:
951.571
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@H]4CC[C@@H](CC4)NC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |wU:28.28,wD:31.35,c:64,(4.25,12.11,;3.48,10.78,;5.02,10.78,;3.48,9.24,;2.15,8.47,;.82,9.24,;-.52,8.47,;-.52,6.93,;-1.85,6.16,;-1.85,4.62,;-.52,3.85,;.82,4.62,;.82,6.16,;-.52,2.31,;-1.85,1.54,;-1.85,,;-.52,-.77,;-.52,-2.31,;-1.85,-3.08,;.82,-3.08,;.82,-4.62,;-.72,-4.62,;2.36,-4.62,;.82,-6.16,;-.52,-6.93,;-.52,-8.47,;.82,-9.24,;.82,-10.78,;-.52,-11.55,;-.52,-13.09,;-1.85,-13.86,;-3.19,-13.09,;-3.19,-11.55,;-1.85,-10.78,;-4.52,-13.86,;-5.85,-13.09,;-5.85,-11.55,;-7.19,-10.78,;-8.52,-11.55,;-8.52,-13.09,;-7.19,-13.86,;2.15,-8.47,;2.15,-6.93,;3.48,-9.24,;4.82,-8.47,;3.48,-10.78,;.82,,;2.15,-.77,;3.48,,;3.48,1.54,;4.82,2.31,;6.15,1.54,;7.61,2.02,;8.52,.77,;7.61,-.48,;6.15,,;4.82,-.77,;.82,1.54,;.82,10.78,;2.15,11.55,;-.52,11.55,;-1.85,10.78,;-3.19,11.55,;-3.19,13.09,;-4.52,13.86,;-1.85,13.86,;-.52,13.09,)|