Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50365230
Substrate
n/a
Meas. Tech.
DHODH Kinetic Analysis
IC50
72.0±28 nM
Citation
 Phillips, M; Palmer, M; Charman, SA; Watts, KS; Gerasyuto, AI; Krilov, G Anti-malarial agents US Patent  US11903936 Publication Date 2/20/2024 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
62960.21
Organism:
malaria parasite P. vivax
Description:
A0A1G4H0K4
Residue:
572
Sequence:
MLRHSCLREKGNLIGGSLLRGTSAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWYGCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDKTKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKYVDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA
  
Inhibitor
Name:
BDBM50365230
Synonyms:
CHEMBL1956285 | US11903936, Compound DSM265 | US9238653, Table 5, Compound 10
Type:
Small organic molecule
Emp. Form.:
C14H12F7N5S
Mol. Mass.:
415.332
SMILES:
Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F
Structure:
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