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Target
Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM652313
Substrate
n/a
Meas. Tech.
Biochemical QPCT and QPCTL Activity Assay
IC50
1.000±n/a nM
Citation
 WILLWACHER, J; BINDER, FP; DAHMANN, G; YANG HAMILTON, JY; HANDSCHUH, SR; REINDL, SA PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN US Patent  US20240059675 Publication Date 2/22/2024 
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
  
Inhibitor
Name:
BDBM652313
Synonyms:
US20240059675, Example 16
Type:
Small organic molecule
Emp. Form.:
C20H19F2N7
Mol. Mass.:
395.4086
SMILES:
Cc1cc(C#N)c(N2CCC(F)(CC2)c2nncn2C)c(n1)-c1ccc(F)nc1
Structure:
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