Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM652327
Substrate
n/a
Meas. Tech.
Biochemical QPCT and QPCTL Activity Assay
IC50
2.00±n/a nM
Citation
 WILLWACHER, J; BINDER, FP; DAHMANN, G; YANG HAMILTON, JY; HANDSCHUH, SR; REINDL, SA PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN US Patent  US20240059675 Publication Date 2/22/2024 
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
  
Inhibitor
Name:
BDBM652327
Synonyms:
US20240059675, Example 29
Type:
Small organic molecule
Emp. Form.:
C24H23F4N9
Mol. Mass.:
513.4933
SMILES:
Cn1cnnc1C1(F)CCN(CC1)c1c(ccnc1-c1cnc2nn(cc2c1)C(C)(C)C(F)(F)F)C#N
Structure:
Search PDB for entries with ligand similarity: