Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329858
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
<10±n/a nM
Citation
Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US9663525 Publication Date 5/30/2017
More Info.:
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
Inhibitor
Name:
BDBM329858
Synonyms:
(rac)-((1R,2R,3S,4R)-2,3-Dihydroxy-4-((2-(2-methoxy-5-(trifluoromethoxy)- | US10202389, Compound I-102 | US9663525, Compound I-066 | US9663525, Compound I-102 | US9796725, Compound I-066
Type:
Small organic molecule
Emp. Form.:
C20H22F3N5O7S
Mol. Mass.:
533.478
SMILES:
COc1ccc(OC(F)(F)F)cc1-c1cc2nccc(N[C@@H]3C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]3O)n2n1 |r|