Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50248261
Substrate
n/a
Meas. Tech.
Histone H3 Acetylation Assay
IC50
238±n/a nM
Citation
 Chen, D; Song, HY; Sun, ET; Yu, N; Zou, Y Benzimidazole derivatives: preparation and pharmaceutical applications US Patent  US10201527 Publication Date 2/12/2019 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50248261
Synonyms:
CHEMBL475145 | N-hydroxy-3-(1-(3-hydroxypropyl)-2-isobutyl-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 21 | US10736881, Compound 21 | US8551988, 21
Type:
Small organic molecule
Emp. Form.:
C17H23N3O3
Mol. Mass.:
317.3828
SMILES:
CC(C)Cc1nc2cc(\C=C\C(=O)NO)ccc2n1CCCO
Structure:
Search PDB for entries with ligand similarity: