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Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM214650
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
23.0±n/a nM
Citation
 Zorn, L; Eis, K; Schulze, V; Sülzle, D; Puehler, F; Lienau, P; Bömer, U; Petersen, K; Hägebarth, A Aminoimidazopyridazines US Patent  US9783543 Publication Date 10/10/2017 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM214650
Synonyms:
US10688093, Compound 229_0237_0073 | US11701353, Compound 229_0237_0073 | US9284319, R8 | US9730929, Example R8 | US9783543, R8
Type:
Small organic molecule
Emp. Form.:
C20H15N5O
Mol. Mass.:
341.366
SMILES:
C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Structure:
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