Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Ligand
BDBM14711
Substrate
BDBM15346
Meas. Tech.
DHODH Inhibition Assay
IC50
200000±n/a nM
Citation
 Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 280:21847-53 (2005) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Synonyms:
DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
39678.95
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli.
Residue:
366
Sequence:
ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM14711
Synonyms:
Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-methyl-3-nitrobenzamide | benzamide compound 3
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2N2O3
Mol. Mass.:
325.147
SMILES:
Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cc(Cl)cc(Cl)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM15346
Synonyms:
2,3-dimethoxy-5-methyl-cyclohexa-2,5-diene-1,4-dione | 2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione | Ubiquinone-0 (CoQ0)
Type:
Small organic molecule
Emp. Form.:
C9H10O4
Mol. Mass.:
182.1733
SMILES:
COC1=C(OC)C(=O)C(C)=CC1=O |c:2,9|
Structure:
Search PDB for entries with ligand similarity: