Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM347784
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
9600±n/a nM
Citation
 Fieldhouse, C; Glen, A; Fujimoto, T; Robinson, JS Substituted cyclopentanes, tetrahydrofuranes and pyrrolidines as orexin receptor antagonists US Patent  US9790220 Publication Date 10/17/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM347784
Synonyms:
US9790220, Example 17
Type:
Small organic molecule
Emp. Form.:
C20H18F4N4O2S
Mol. Mass.:
454.441
SMILES:
COc1ccc(nc1C(=O)N[C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: