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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM165931
Substrate
n/a
Meas. Tech.
The [3H]-methyllycaconitine binding assay
Ki
17.0±n/a nM
Citation
 Luithle, J; Böβ, F; Erb, C; Hafner, F; Schnizler, K; Flessner, T; Van Kampen, M; Van Der Staay, F 2-heteroaryl carboxamides US Patent  US10214524 Publication Date 2/26/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM165931
Synonyms:
US10214524, Example 116 | US9067931, 116
Type:
Small organic molecule
Emp. Form.:
C26H27N3O3
Mol. Mass.:
429.5109
SMILES:
O=C(Nc1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2)C1CC1 |r,wU:21.23,(5.81,-4,;6.58,-2.67,;5.81,-1.33,;4.27,-1.33,;3.5,-2.67,;1.96,-2.67,;1.19,-1.33,;1.96,,;3.5,,;1.19,1.33,;1.96,2.67,;1.19,4,;-.35,4,;-1.12,2.67,;-2.63,2.35,;-2.79,.82,;-1.38,.19,;-.35,1.33,;-4.12,.05,;-4.12,-1.49,;-5.45,.82,;-6.79,.05,;-6.79,-1.49,;-8.12,-2.26,;-9.45,-1.49,;-9.45,.05,;-8.12,.82,;-7.46,-.45,;-8.89,-.89,;8.12,-2.67,;9.45,-3.44,;9.45,-1.9,)|
Structure:
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