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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM246893
Substrate
n/a
Meas. Tech.
TAM Kinase Assay
Temperature
298.15±n/a K
IC50
>3000±n/a nM
Comments
extracted
Citation
 Li, Y; Burns, DM; Feng, H; Glenn, J; He, C; Huang, T; Mei, S; Pan, J; Wang, X; Ye, Y Pyrrolopyrimidine derivatives as TAM inhibitors US Patent  US10053465 Publication Date 8/21/2018 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM246893
Synonyms:
5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrimidin-1-yl)ethyl]- 6-cyano-2-ethoxy-5- methylphenyl}-N,N- dimethylpyridine-2- carboxamide | US10053465, 31 | US10065963, Compound 31 | US10376513, Example 344 | US10519163, Example 31 | US10646492, Example 314 | US10675284, Example 31 | US11136326, Example 31 | US11433071, Example 314-2 | US9730939, Example 314
Type:
Small organic molecule
Emp. Form.:
C26H28N8O2
Mol. Mass.:
484.5529
SMILES:
CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Structure:
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