Reaction Details Report a problem with these data
Target
Focal adhesion kinase 1 [410-689]
Ligand
BDBM418862
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
<0.595±n/a nM
Citation
 Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent  US10450297 Publication Date 10/22/2019 
Target
Name:
Focal adhesion kinase 1 [410-689]
Synonyms:
FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32163.33
Organism:
Homo sapiens (Human)
Description:
aa 410-689
Residue:
280
Sequence:
PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
  
Inhibitor
Name:
BDBM418862
Synonyms:
N-[2-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)phenyl]-N- methylmethanesulfonamide (362), hydrochloride salt | US10450297, Example 362 | US10450297, Example 363
Type:
Small organic molecule
Emp. Form.:
C22H25F3N6O2S
Mol. Mass.:
494.533
SMILES:
C[C@H](N)c1ccc(Nc2ncc(c(NCc3ccccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1 |r|
Structure:
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