Reaction Details Report a problem with these data
Target
Focal adhesion kinase 1 [410-689]
Ligand
BDBM418912
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
<0.595±n/a nM
Citation
 Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent  US10450297 Publication Date 10/22/2019 
Target
Name:
Focal adhesion kinase 1 [410-689]
Synonyms:
FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32163.33
Organism:
Homo sapiens (Human)
Description:
aa 410-689
Residue:
280
Sequence:
PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
  
Inhibitor
Name:
BDBM418912
Synonyms:
N-[3-({[2-{[4-(1,2- dihydroxyethyl)phenyl]amino}-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)pyridin-2-yl]-N- methylmethane-sulfonamide (412), hydrochloride salt | US10450297, Example 412
Type:
Small organic molecule
Emp. Form.:
C21H23F3N6O4S
Mol. Mass.:
512.505
SMILES:
CN(c1ncccc1CNc1nc(Nc2ccc(cc2)C(O)CO)ncc1C(F)(F)F)S(C)(=O)=O
Structure:
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