Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM22504
Substrate
BDBM10852
Meas. Tech.
96-Well Adherent Reporter Cell Assay
Temperature
295.15±n/a K
EC50
501±130 nM
Comments
160 +/- 7 % of the maximal response relative to the activity produced by linoleic acid.
Citation
 McKeown, SC; Corbett, DF; Goetz, AS; Littleton, TR; Bigham, E; Briscoe, CP; Peat, AJ; Watson, SP; Hickey, DM Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. Bioorg Med Chem Lett 17:1584-9 (2007) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Human
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM22504
Synonyms:
3-(3-{[(4-phenylphenyl)methyl]amino}phenyl)propanoic acid | carboxylic acid agonist, 21
Type:
Small organic molecule
Emp. Form.:
C22H21NO2
Mol. Mass.:
331.4076
SMILES:
OC(=O)CCc1cccc(NCc2ccc(cc2)-c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate