Reaction Details
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Free fatty acid receptor 1
Ligand
BDBM22511
Substrate
BDBM10852
Meas. Tech.
96-Well Adherent Reporter Cell Assay
Temperature
295.15±n/a K
EC50
1995±143 nM
Comments
143 +/- 34 % of the maximal response relative to the activity produced by linoleic acid.
Citation
McKeown, SC; Corbett, DF; Goetz, AS; Littleton, TR; Bigham, E; Briscoe, CP; Peat, AJ; Watson, SP; Hickey, DM Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. Bioorg Med Chem Lett 17:1584-9 (2007) [PubMed] Article More Info.:
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Human
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Inhibitor
Name:
BDBM22511
Synonyms:
3-(4-{[(5-chlorothiophen-2-yl)methyl]amino}phenyl)propanoic acid | carboxylic acid agonist, 28
Type:
Small organic molecule
Emp. Form.:
C14H14ClNO2S
Mol. Mass.:
295.784
SMILES:
OC(=O)CCc1ccc(NCc2ccc(Cl)s2)cc1
Structure:
Substrate