Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375093
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
4.00±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375093
Synonyms:
(1S,2S)-2-(5-{(R)-4-[4-(3-Hydroxy-3-methyl-butoxy)-2,6-dimethyl-phenyl]-indan-1-ylamino}-pyrazin-2-yl)-cyclopropanecarboxylic acid | US10253004, Example 7
Type:
Small organic molecule
Emp. Form.:
C30H35N3O4
Mol. Mass.:
501.6166
SMILES:
Cc1cc(OCCC(C)(C)O)cc(C)c1-c1cccc2[C@@H](CCc12)Nc1cnc(cn1)[C@H]1C[C@@H]1C(O)=O |r,wU:31.34,20.26,wD:33.38,(-1.75,.92,;-3.26,.6,;-4.29,1.75,;-5.79,1.43,;-6.82,2.57,;-8.33,2.25,;-9.36,3.4,;-10.87,3.08,;-11.9,4.22,;-11.34,1.61,;-10.87,4.62,;-6.27,-.04,;-5.24,-1.18,;-5.71,-2.65,;-3.73,-.86,;-2.7,-2.01,;-3.18,-3.47,;-2.15,-4.62,;-.64,-4.3,;-.16,-2.83,;1.24,-2.2,;1.08,-.67,;-.42,-.35,;-1.2,-1.69,;2.56,-2.97,;3.89,-2.2,;3.89,-.66,;5.23,.11,;6.56,-.66,;6.56,-2.2,;5.23,-2.97,;7.9,.11,;9.23,.88,;9.23,-.66,;10.56,.11,;11.9,-.66,;10.56,1.65,)|
Structure:
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