Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM261815
Substrate
n/a
Meas. Tech.
Test for Antagonism
Temperature
298.15±n/a K
IC50
16.1±n/a nM
Comments
extracted
Citation
 Peters, O; Bräuer, N; Blume, T; Ter Laak, A; Zorn, L; Nagel, J; Kaulfuss, S; Langer, G; Kuhnke, J Benzimidazole derivatives as EP4 antagonists US Patent  US9708311 Publication Date 7/18/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM261815
Synonyms:
N-[(2,2-Dimethylpropyl)sulphonyl]-2-(9-ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H-benzimidazole-5-carboxamide | US9708311, 66
Type:
Small organic molecule
Emp. Form.:
C30H34N4O4S
Mol. Mass.:
546.68
SMILES:
CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(=O)NS(=O)(=O)CC(C)(C)C
Structure:
Search PDB for entries with ligand similarity: