Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM263583
Substrate
n/a
Meas. Tech.
WNT Pathway Reporter Gene Assay
IC50
20.0±n/a nM
Citation
 An, S Compounds for treatment of fibrosis diseases US Patent  US10285988 Publication Date 5/14/2019 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM263583
Synonyms:
US10087181, Compound 23 | US10285988, Compound 23 | US9713612, 23
Type:
Small organic molecule
Emp. Form.:
C27H21FN4
Mol. Mass.:
420.4808
SMILES:
Cc1cc(ccn1)-c1ccc(CNc2nccc3cc(ncc23)-c2ccccc2F)cc1
Structure:
Search PDB for entries with ligand similarity: