Reaction Details Report a problem with these data
Target
Matrilysin
Ligand
BDBM26551
Substrate
BDBM23499
Meas. Tech.
MMP Inhibition Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
33000±n/a nM
Citation
Govinda Rao, B; Bandarage, UK; Wang, T; Come, JH; Perola, E; Wei, Y; Tian, SK; Saunders, JO Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides. Bioorg Med Chem Lett 17:2250-3 (2007) [PubMed] Article
More Info.:
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
Inhibitor
Name:
BDBM26551
Synonyms:
4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)benzene-1-sulfonamide | butynyloxy containing compound, 2
Type:
Small organic molecule
Emp. Form.:
C13H17NO3S2
Mol. Mass.:
299.409
SMILES:
CC#CCOc1ccc(cc1)S(=O)(=O)N(C)CCS