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Target
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
Ligand
BDBM392201
Substrate
n/a
Meas. Tech.
RORgamma Gal4 Reporter Gene Assay (REN)
IC50
1.58±n/a nM
Citation
 Gege, C; Steeneck, C; Kinzel, O; Kleymann, G; Hoffmann, T Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] US Patent  US10301272 Publication Date 5/28/2019 
Target
Name:
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
Synonyms:
Isoform 2 of Nuclear receptor ROR-gamma | NR1F3 | Nuclear receptor ROR-gamma (RORgT) | Nuclear receptor ROR-gammaT | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma (RORgT)
Type:
Protein
Mol. Mass.:
55831.73
Organism:
Human
Description:
P51449-2
Residue:
497
Sequence:
MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM392201
Synonyms:
US10301272, Example 25/1
Type:
Small organic molecule
Emp. Form.:
C30H37N3O5S2
Mol. Mass.:
583.762
SMILES:
CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(sc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12 |r,wU:27.28,wD:29.33,(6.26,-1.94,;7.8,-1.94,;8.57,-3.27,;7.03,-3.27,;8.57,-.6,;7.8,.73,;8.57,2.06,;9.29,1.13,;6.26,.73,;5.49,-.6,;3.95,-.6,;3.18,.73,;1.64,.73,;.73,1.98,;-.73,1.5,;-.73,-.04,;.73,-.52,;1.13,-2,;.04,-3.09,;-1.44,-2.69,;-2.53,-3.78,;-2.14,-5.27,;-.65,-5.67,;.44,-4.58,;-2.07,2.27,;-2.07,3.81,;-3.4,1.5,;-4.73,2.27,;-6.22,1.87,;-6.62,3.36,;-5.13,3.76,;-7.95,4.13,;-9.29,3.36,;-7.95,5.67,;3.95,2.06,;3.18,3.4,;3.95,4.73,;5.49,4.73,;6.26,3.4,;5.49,2.06,)|
Structure:
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