Reaction Details Report a problem with these data
Target
Alpha-carbonic anhydrase domain-containing protein
Ligand
BDBM25909
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
9.9±n/a nM
Citation
Güzel, O; Innocenti, A; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem 17:3212-5 (2009) [PubMed] Article
More Info.:
Target
Name:
Alpha-carbonic anhydrase domain-containing protein
Synonyms:
CAH-4b | alpha-Carbonic Anhydrase | ceCA
Type:
Enzyme
Mol. Mass.:
26169.24
Organism:
Caenorhabditis elegans
Description:
Q8WQD8
Residue:
235
Sequence:
MAAAQRQSPIDIVPQHVCCDTDVCKADALNIDYKSGDCCDVLVSEGGFLVNVKRNCGTFLTANHLPSSKFALAQFHAHWGSNSKEGSEHFLDGKQLSGEVHFVFWNTSYESFNVALSKPDGLAVVGVFLKEGKYNDNYHGLIDTVRKATGNATPIAMPKDFHIEHLLPSPDKREFVTYLGSLTTPPYNECVIWTLFTEPVEVSFGQLNVLRNIIPANHRACQDRCDREIRSSFNF
Inhibitor
Name:
BDBM25909
Synonyms:
3-(3-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2e | indole sulfonamide, 8e
Type:
Small organic molecule
Emp. Form.:
C15H13FN4O3S
Mol. Mass.:
348.352
SMILES:
NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(F)c1)S(N)(=O)=O