Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM31749
Substrate
n/a
Meas. Tech.
MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors
IC50
52500±2000 nM
Citation
 PubChem, PC MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM31749
Synonyms:
1,1-diketo-6-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-3-carboxylic acid | 6-methyl-1,1-bis(oxidanylidene)-3,4-dihydro-2H-1,2,4-benzothiadiazine-3-carboxylic acid | 6-methyl-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-3-carboxylic acid | MLS-0111550.0001 | cid_16654597
Type:
Small organic molecule
Emp. Form.:
C9H10N2O4S
Mol. Mass.:
242.252
SMILES:
Cc1ccc2c(NC(NS2(=O)=O)C(O)=O)c1
Structure:
Search PDB for entries with ligand similarity: