Reaction Details Report a problem with these data
Target
Mothers against decapentaplegic homolog 3
Ligand
BDBM41970
Substrate
n/a
Meas. Tech.
SMAD Transcription Factor Inhibitors Secondary Dose Response Confirmation
IC50
>40000±n/a nM
Citation
 PubChem, PC SMAD Transcription Factor Inhibitors Secondary Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Mothers against decapentaplegic homolog 3
Synonyms:
MADH3 | SMAD3 | SMAD3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48085.78
Organism:
Homo sapiens (Human)
Description:
gi_5174513
Residue:
425
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
  
Inhibitor
Name:
BDBM41970
Synonyms:
6-[1-pyrrolidinyl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol | 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol | 6-[pyrrolidino-(3,4,5-trimethoxyphenyl)methyl]sesamol | cid_340208
Type:
Small organic molecule
Emp. Form.:
C21H25NO6
Mol. Mass.:
387.4263
SMILES:
COc1cc(cc(OC)c1OC)C(N1CCCC1)c1cc2OCOc2cc1O
Structure:
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