Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43526
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Human
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43526
Synonyms:
2-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-1H-quinazolin-4-one | 2-[2-[2,4-bis(oxidanyl)phenyl]-2-oxidanylidene-ethyl]sulfanyl-1H-quinazolin-4-one | 2-[[2-(2,4-dihydroxyphenyl)-2-keto-ethyl]thio]-1H-quinazolin-4-one | 2-[[2-(2,4-dihydroxyphenyl)-2-oxoethyl]thio]-1H-quinazolin-4-one | MLS000714554 | SMR000274533 | cid_772018
Type:
Small organic molecule
Emp. Form.:
C16H12N2O4S
Mol. Mass.:
328.342
SMILES:
Oc1ccc(C(=O)CSc2nc3ccccc3c(=O)[nH]2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: