Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM49186
Substrate
n/a
Meas. Tech.
Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response
EC50
5240±n/a nM
Citation
 PubChem, PC Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM49186
Synonyms:
4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid benzo[1,3]dioxol-5-ylamide | MLS000074515 | N-(1,3-benzodioxol-5-yl)-4-methyl-5-thieno[3,2-b]pyrrolecarboxamide | N-(1,3-benzodioxol-5-yl)-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide | N-(1,3-benzodioxol-5-yl)-4-methylthieno[3,2-b]pyrrole-5-carboxamide | SMR000007360 | cid_653902
Type:
Small organic molecule
Emp. Form.:
C15H12N2O3S
Mol. Mass.:
300.332
SMILES:
Cn1c(cc2sccc12)C(=O)Nc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: