Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61373
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
24160±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61373
Synonyms:
3-(4-bromophenyl)sulfonyl-1-[4-(4-fluorophenyl)-1-piperazinyl]-1-propanone | 3-(4-bromophenyl)sulfonyl-1-[4-(4-fluorophenyl)piperazin-1-yl]propan-1-one | 3-brosyl-1-[4-(4-fluorophenyl)piperazino]propan-1-one | MLS001030226 | SMR000635586 | cid_3495780
Type:
Small organic molecule
Emp. Form.:
C19H20BrFN2O3S
Mol. Mass.:
455.341
SMILES:
Fc1ccc(cc1)N1CCN(CC1)C(=O)CCS(=O)(=O)c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: