Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM43386
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
4560±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM43386
Synonyms:
(E)-1-(2-prop-2-enylsulfanylbenzimidazol-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | (E)-1-[2-(allylthio)benzimidazol-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | (E)-1-[2-(prop-2-enylthio)-1-benzimidazolyl]-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one | 2-(allylthio)-1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-1H-benzimidazole | MLS000577033 | SMR000198113 | cid_5737516
Type:
Small organic molecule
Emp. Form.:
C22H22N2O4S
Mol. Mass.:
410.486
SMILES:
COc1cc(\C=C\C(=O)n2c(SCC=C)nc3ccccc23)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: