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Target
NACHT, LRR and PYD domains-containing protein 3
Ligand
BDBM50653
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen
IC50
566±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen PubChem Bioassay (2010)[AID] 
Target
Name:
NACHT, LRR and PYD domains-containing protein 3
Synonyms:
C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
118173.88
Organism:
Homo sapiens (Human)
Description:
Q96P20
Residue:
1036
Sequence:
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
  
Inhibitor
Name:
BDBM50653
Synonyms:
(3Z)-3-[(2-chloranyl-4-nitro-phenyl)hydrazinylidene]-N-(3-chlorophenyl)-6-oxidanylidene-cyclohexa-1,4-diene-1-carboxamide | (3Z)-3-[(2-chloro-4-nitro-phenyl)hydrazono]-N-(3-chlorophenyl)-6-keto-cyclohexa-1,4-diene-1-carboxamide | (3Z)-3-[(2-chloro-4-nitrophenyl)hydrazinylidene]-N-(3-chlorophenyl)-6-oxo-1-cyclohexa-1,4-dienecarboxamide | (3Z)-3-[(2-chloro-4-nitrophenyl)hydrazinylidene]-N-(3-chlorophenyl)-6-oxocyclohexa-1,4-diene-1-carboxamide | MLS000738259 | SMR000528595 | Salicylanilide, 3'-chloro-5-[(2-chloro-4-nitrophenyl)azo]- | cid_6147886
Type:
Small organic molecule
Emp. Form.:
C19H12Cl2N4O4
Mol. Mass.:
431.229
SMILES:
[O-][N+](=O)c1ccc(\[NH+]=N\c2ccc(=O)[c-](c2)C(=O)Nc2cccc(Cl)c2)c(Cl)c1
Structure:
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