Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78081
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
16300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78081
Synonyms:
(E)-6,6,7,7-tetrafluoro-5-hydroxy-1,5-diphenyl-1-hepten-3-one | (E)-6,6,7,7-tetrafluoro-5-hydroxy-1,5-diphenyl-hept-1-en-3-one | (E)-6,6,7,7-tetrafluoro-5-hydroxy-1,5-diphenylhept-1-en-3-one | (E)-6,6,7,7-tetrakis(fluoranyl)-5-oxidanyl-1,5-diphenyl-hept-1-en-3-one | MLS000532188 | SMR000137129 | cid_5290862
Type:
Small organic molecule
Emp. Form.:
C19H16F4O2
Mol. Mass.:
352.3228
SMILES:
OC(CC(=O)C=Cc1ccccc1)(c1ccccc1)C(F)(F)C(F)F |w:5.4|
Structure:
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