Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80415
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1670±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80415
Synonyms:
1,3,3-Trimethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3H-indolium | MLS000556742 | SMR000173748 | cid_11958735 | methyl-phenyl-[(2Z)-2-(1,3,3-trimethyl-2-indolylidene)ethylidene]ammonium;iodide | methyl-phenyl-[(2Z)-2-(1,3,3-trimethylindol-2-ylidene)ethylidene]azanium;iodide | methyl-phenyl-[(2Z)-2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]ammonium;iodide
Type:
Small organic molecule
Emp. Form.:
C20H23N2
Mol. Mass.:
291.4095
SMILES:
CN(\C=C\C1=[N+](C)c2ccccc2C1(C)C)c1ccccc1 |c:4|
Structure:
