Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80488
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2030±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80488
Synonyms:
11-(1-methylpiperidin-1-ium-1-yl)undecyl acetate;iodide | 11-(1-methylpiperidin-1-ium-1-yl)undecyl ethanoate;iodide | MLS000712970 | SMR000282737 | acetic acid 11-(1-methyl-1-piperidin-1-iumyl)undecyl ester;iodide | acetic acid 11-(1-methylpiperidin-1-ium-1-yl)undecyl ester;iodide | cid_16192865
Type:
Small organic molecule
Emp. Form.:
C19H38NO2
Mol. Mass.:
312.51
SMILES:
CC(=O)OCCCCCCCCCCC[N+]1(C)CCCCC1
Structure:
