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Target
Urokinase-type plasminogen activator
Ligand
BDBM81609
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
4.2e+3± 4e+2 nM
Citation
 Heynekamp, JJ; Hunsaker, LA; Vander Jagt, TA; Deck, LM; Vander Jagt, DL Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator. BMC Chem Biol 6:1 (2006) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Human
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM81609
Synonyms:
Isocoumarin, 10a
Type:
Small organic molecule
Emp. Form.:
C11H8BrNO5
Mol. Mass.:
314.089
SMILES:
BrCCOc1cc2ccc(cc2c(=O)o1)N(=O)=O
Structure:
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