Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM54226
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1719±39 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM54226
Synonyms:
(3-amino-7-methoxy-1-pyrazolo[3,4-b]quinolinyl)-(4-chloro-3-nitrophenyl)methanone | (3-amino-7-methoxy-pyrazolo[3,4-b]quinolin-1-yl)-(4-chloro-3-nitro-phenyl)methanone | (3-amino-7-methoxypyrazolo[3,4-b]quinolin-1-yl)-(4-chloro-3-nitrophenyl)methanone | (3-azanyl-7-methoxy-pyrazolo[3,4-b]quinolin-1-yl)-(4-chloranyl-3-nitro-phenyl)methanone | 1-(4-chloro-3-nitrobenzoyl)-7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine | MLS000582480 | SMR000206466 | cid_12004545
Type:
Small organic molecule
Emp. Form.:
C18H12ClN5O4
Mol. Mass.:
397.772
SMILES:
COc1ccc2cc3c(N)nn(C(=O)c4ccc(Cl)c(c4)[N+]([O-])=O)c3nc2c1
Structure:
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