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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM83182
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1017±65 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM83182
Synonyms:
4-[(E)-[[4-(2-methylindolizin-3-yl)carbonyl-2-nitro-phenyl]hydrazinylidene]methyl]benzoic acid | 4-[(E)-[[4-(2-methylindolizine-3-carbonyl)-2-nitro-phenyl]hydrazono]methyl]benzoic acid | 4-[(E)-[[4-(2-methylindolizine-3-carbonyl)-2-nitrophenyl]hydrazinylidene]methyl]benzoic acid | 4-[(E)-[[4-[(2-methyl-3-indolizinyl)-oxomethyl]-2-nitrophenyl]hydrazinylidene]methyl]benzoic acid | MLS002636100 | SMR000241765 | cid_9645146
Type:
Small organic molecule
Emp. Form.:
C24H18N4O5
Mol. Mass.:
442.4235
SMILES:
Cc1cc2ccccn2c1C(=O)c1ccc([NH+]=N[CH-]c2ccc(cc2)C(O)=O)c(c1)[N+]([O-])=O |w:16.17|
Structure:
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