Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM51963
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
6650±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM51963
Synonyms:
MLS000557398 | N-[5-(2-Fluoro-benzylsulfanylmethyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethyl-propionamide | N-[5-[(2-fluorophenyl)methylsulfanylmethyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propanamide | N-[5-[(2-fluorophenyl)methylsulfanylmethyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide | N-[5-[[(2-fluorobenzyl)thio]methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide | N-[5-[[(2-fluorophenyl)methylthio]methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide | SMR000148315 | cid_945654
Type:
Small organic molecule
Emp. Form.:
C15H18FN3OS2
Mol. Mass.:
339.451
SMILES:
CC(C)(C)C(=O)Nc1nnc(CSCc2ccccc2F)s1
Structure:
Search PDB for entries with ligand similarity: