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Target
Type-1 angiotensin II receptor
Ligand
BDBM50003398
Substrate
n/a
Meas. Tech.
ChEBML_36783
IC50
66±n/a nM
Citation
 Bradbury, RH; Allott, CP; Dennis, M; Fisher, E; Major, JS; Masek, BB; Oldham, AA; Pearce, RJ; Rankine, N; Revill, JM New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives. J Med Chem 35:4027-38 (1992) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor
Type:
PROTEIN
Mol. Mass.:
41004.19
Organism:
Cavia porcellus
Description:
ChEMBL_36783
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
  
Inhibitor
Name:
BDBM50003398
Synonyms:
2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-quinoline-6-carboxylic acid methyl ester | CHEMBL129872
Type:
Small organic molecule
Emp. Form.:
C27H23N5O3
Mol. Mass.:
465.5032
SMILES:
CCc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2cc(ccc2n1)C(=O)OC
Structure:
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