Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50005227
Substrate
n/a
Meas. Tech.
ChEBML_164926
IC50
4.1±n/a nM
Citation
 Carceller, E; Merlos, M; Giral, M; Bartrolí, J; García-Rafanell, J; Forn, J 4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists. J Med Chem 35:676-83 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Guinea pig
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50005227
Synonyms:
2-({Acetyl-[5-(6-decyloxy-hexyloxy)-tetrahydro-furan-3-ylmethoxycarbonyl]-amino}-methyl)-1-ethyl-pyridinium; iodide | CHEMBL421843
Type:
Small organic molecule
Emp. Form.:
C32H55N2O6
Mol. Mass.:
563.7884
SMILES:
CCCCCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Structure:
Search PDB for entries with ligand similarity: