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Target
Monoglyceride lipase
Ligand
BDBM50250851
Substrate
n/a
Meas. Tech.
ChEBML_1682364
IC50
2.0±n/a nM
Citation
 Butler, CR; Beck, EM; Harris, A; Huang, Z; McAllister, LA; Am Ende, CW; Fennell, K; Foley, TL; Fonseca, K; Hawrylik, SJ; Johnson, DS; Knafels, JD; Mente, S; Noell, GS; Pandit, J; Phillips, TB; Piro, JR; Rogers, BN; Samad, TA; Wang, J; Wan, S; Brodney, MA Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. J Med Chem 60:9860-9873 (2017) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50250851
Synonyms:
CHEMBL4096459
Type:
Small organic molecule
Emp. Form.:
C18H17F6N3O2
Mol. Mass.:
421.3369
SMILES:
FC(F)(F)C(OC(=O)N1CCC(CC1)c1ccn(n1)-c1ccccc1)C(F)(F)F
Structure:
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