Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50261598
Substrate
n/a
Meas. Tech.
ChEBML_1696165
Ki
3.8±n/a nM
Citation
 Angapelly, S; Ramya, PVS; Angeli, A; Del Prete, S; Capasso, C; Arifuddin, M; Supuran, CT Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors. Bioorg Med Chem 25:5726-5732 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50261598
Synonyms:
CHEMBL4081738
Type:
Small organic molecule
Emp. Form.:
C16H13F3N2O3S
Mol. Mass.:
370.346
SMILES:
NS(=O)(=O)c1ccc(NC(=O)\C=C\c2cccc(c2)C(F)(F)F)cc1
Structure:
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