Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50005225
Substrate
n/a
Meas. Tech.
ChEMBL_177423 (CHEMBL784402)
IC50
8.6±n/a nM
Citation
Bartrolí, J; Carceller, E; Merlos, M; García-Rafanell, J; Forn, J Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists. J Med Chem 34:373-86 (1991) [PubMed] Article
More Info.:
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Guinea pig
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
Inhibitor
Name:
BDBM50005225
Synonyms:
2-{[Acetyl-(5-hexadecyloxymethyl-tetrahydro-furan-3-ylmethoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; chloride | 2-{[Acetyl-(5-hexadecyloxymethyl-tetrahydro-furan-3-ylmethoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; iodide | CHEMBL419779
Type:
Small organic molecule
Emp. Form.:
C33H57N2O5
Mol. Mass.:
561.8155
SMILES:
CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1