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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50271833
Substrate
n/a
Meas. Tech.
ChEMBL_1711701 (CHEMBL4121750)
IC50
200±n/a nM
Citation
 Zhang, D; Markoulides, MS; Stepanovs, D; Rydzik, AM; El-Hussein, A; Bon, C; Kamps, JJAG; Umland, KD; Collins, PM; Cahill, ST; Wang, DY; von Delft, F; Brem, J; McDonough, MA; Schofield, CJ Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-?-lactamases. Bioorg Med Chem 26:2928-2936 (2018) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
BLAB_AERHY | Beta-lactamase | cphA
Type:
PROTEIN
Mol. Mass.:
28022.56
Organism:
Aeromonas hydrophila
Description:
ChEMBL_641771
Residue:
254
Sequence:
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
  
Inhibitor
Name:
BDBM50271833
Synonyms:
CHEMBL3792857
Type:
Small organic molecule
Emp. Form.:
C9H5Cl3O2S
Mol. Mass.:
283.559
SMILES:
OC(=O)C(\S)=C\c1c(Cl)ccc(Cl)c1Cl
Structure:
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